| Date | Issuer | Insider | Transaction | Amount | New Balance ⓘ 
                                    The balance of securities held by registered holder at the time of the transaction. Insiders may direct multiple registered holders and hold multiple security types.
                                 | |
|---|---|---|---|---|---|---|
| Filed 2016-03-04 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | Guntermann, Henrich R.K. 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Common Shares00 - Opening Balance-Initial SEDI Report | 15,017 | ||
| Filed 2016-03-04 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | Guntermann, Henrich R.K. 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options00 - Opening Balance-Initial SEDI Report | 121,860 | ||
| Filed 2016-03-04 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | Guntermann, Henrich R.K. 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)00 - Opening Balance-Initial SEDI Report | 72,597 | ||
| Filed 2016-02-29 Tx date 2016-02-29 | $NRI Nuvo Research Inc. | Guntermann, Henrich R.K. 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options97 - Other | -7 vol | 121,860 | |
| Filed 2016-01-06 Tx date 2016-01-01 | $NRI Nuvo Research Inc. | Guntermann, Henrich R.K. 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)59 - Exercise for cash | $-222,748.34 -42,754 vol $5.21 each | 72,597 | |
| Filed 2015-09-24 Tx date 2015-09-21 | $NRI Nuvo Research Inc. | Guntermann, Henrich R.K. 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | $-399,997 -30,769 vol $13.00 each | 121,867 |