| Date | Issuer | Insider | Transaction | Amount | New Balance ⓘ 
                                    The balance of securities held by registered holder at the time of the transaction. Insiders may direct multiple registered holders and hold multiple security types.
                                 | |
|---|---|---|---|---|---|---|
| Filed 2025-07-02 22:08 Tx date 2025-06-27 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Deferred Share Units (DSU)56 - Grant of rights | $11,750 +23,980 vol $0.49 each | 95,273 | |
| Filed 2024-10-08 09:22 Tx date 2024-09-30 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Deferred Share Units (DSU)56 - Grant of rights | $11,749 +19,583 vol $0.60 each | 71,293 | |
| Filed 2023-06-25 23:16 Tx date 2023-06-20 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Deferred Share Units (DSU)56 - Grant of rights | $11,750 +18,077 vol $0.65 each | 51,710 | |
| Filed 2022-05-19 22:01 Tx date 2022-05-18 | $MRV Nuvo Pharmaceuticals Inc. (d/b/a Miravo Healthcare) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Deferred Share Unit Plan (DSU)56 - Grant of rights | +12,113 vol | 19,793 | |
| Filed 2022-05-17 12:57 Tx date 2022-05-13 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Deferred Share Units (DSU)56 - Grant of rights | +16,096 vol | 33,633 | |
| Filed 2022-04-03 21:21 Tx date 2022-03-29 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -44,368 vol | 117,658 | |
| Filed 2021-12-28 11:40 Tx date 2021-12-22 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Deferred Share Units (DSU)56 - Grant of rights | +17,537 vol | 17,537 | |
| Filed 2021-12-28 11:38 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Deferred Share Units (DSU)00 - Opening Balance-Initial SEDI Report | |||
| Filed 2021-12-22 11:30 Tx date 2021-12-21 | $MRV Nuvo Pharmaceuticals Inc. (d/b/a Miravo Healthcare) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options38 - Redemption, retraction, cancellation, repurchase | -44,368 vol | 275,103 | |
| Filed 2021-08-26 15:31 Tx date 2021-08-16 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | $-10,623.7472 -8,812 vol $1.21 each | 162,026 | |
| Filed 2021-08-17 08:35 Tx date 2021-08-17 | $MRV Nuvo Pharmaceuticals Inc. (d/b/a Miravo Healthcare) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -8,812 vol | 319,471 | |
| Filed 2021-05-21 12:14 Tx date 2021-05-20 | $MRV Nuvo Pharmaceuticals Inc. (d/b/a Miravo Healthcare) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Deferred Share Unit Plan (DSU)56 - Grant of rights | +7,680 vol | 7,680 | |
| Filed 2020-08-21 21:36 Tx date 2020-08-17 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | $6,000 +10,000 vol $0.60 each | 170,838 | |
| Filed 2020-06-17 15:52 Tx date 2020-06-17 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -16,608 vol | 160,838 | |
| Filed 2020-06-16 16:06 Tx date 2020-06-16 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -16,608 vol | 328,283 | |
| Filed 2020-05-14 13:58 Tx date 2020-05-13 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +7,000 vol | 344,891 | |
| Filed 2019-08-19 15:30 Tx date 2019-08-19 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +7,000 vol | 337,891 | |
| Filed 2019-05-25 14:49 Tx date 2019-05-21 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | $7,800 +10,000 vol $0.78 each | 177,446 | |
| Filed 2019-05-24 12:09 Tx date 2019-05-21 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | $7,800 +10,000 vol $0.78 each | ||
| Filed 2019-05-24 12:09 Tx date 2019-05-21 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | $7,800 +10,000 vol $0.78 each | 177,446 | |
| Filed 2019-01-08 Tx date 2019-01-04 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +10,000 vol | 167,446 | |
| Filed 2019-01-03 Tx date 2019-01-03 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)38 - Redemption, retraction, cancellation, repurchase | -17,195 vol | 0 | |
| Filed 2019-01-03 Tx date 2019-01-03 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)38 - Redemption, retraction, cancellation, repurchase | -17,195 vol | 0 | |
| Filed 2018-04-06 Tx date 2018-04-03 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +10,000 vol | 157,446 | |
| Filed 2018-03-29 Tx date 2017-12-06 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -53,846 vol | ||
| Filed 2018-03-29 Tx date 2017-11-07 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -53,846 vol | 323,891 | |
| Filed 2018-03-29 Tx date 2017-12-06 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -53,846 vol | ||
| Filed 2018-03-29 Tx date 2017-11-07 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -53,846 vol | 147,446 | |
| Filed 2018-03-29 Tx date 2017-12-06 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -53,846 vol | ||
| Filed 2018-03-28 Tx date 2018-03-28 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +7,000 vol | 330,891 | |
| Filed 2018-03-16 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Holder: Spousal TFSA (Control or Direction)
                                
                             | Common Shares00 - Opening Balance-Initial SEDI Report | |||
| Filed 2018-03-16 Tx date 2018-03-13 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Holder: TFSA (Indirect Ownership)
                                
                             | Common Shares57 - Exercise of rights | $15,999 +30,188 vol $0.53 each | 30,188 | |
| Filed 2018-03-16 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Rights Crescita Rights Offering00 - Opening Balance-Initial SEDI Report | |||
| Filed 2018-03-16 Tx date 2018-03-13 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Rights Crescita Rights Offering57 - Exercise of rights | $-40,000.16 -75,472 vol $0.53 each | 0 | |
| Filed 2018-03-16 Tx date 2018-02-16 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Rights Crescita Rights Offering56 - Grant of rights | +75,472 vol | 75,472 | |
| Filed 2018-03-16 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Holder: TFSA (Indirect Ownership)
                                
                             | Common Shares00 - Opening Balance-Initial SEDI Report | |||
| Filed 2018-03-16 Tx date 2018-03-13 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Holder: Spousal TFSA (Control or Direction)
                                
                             | Common Shares57 - Exercise of rights | $4,000 +7,548 vol $0.53 each | 7,548 | |
| Filed 2018-03-13 Tx date 2018-03-13 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Common Shares90 - Change in the nature of ownership | -473 vol | 155,313 | |
| Filed 2018-03-13 Tx date 2004-09-21 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Holder: RRSP (Indirect Ownership)
                                
                             | Common Shares00 - Opening Balance-Initial SEDI Report | |||
| Filed 2018-03-13 Tx date 2018-03-13 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Holder: RRSP (Indirect Ownership)
                                
                             | Common Shares90 - Change in the nature of ownership | +473 vol | 473 | |
| Filed 2018-01-03 Tx date 2018-01-01 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)59 - Exercise for cash | $-82,080.80 -22,184 vol $3.70 each | 17,195 | |
| Filed 2018-01-03 Tx date 2018-01-01 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)38 - Redemption, retraction, cancellation, repurchase | -17,193 vol | 39,379 | |
| Filed 2018-01-03 Tx date 2018-01-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)38 - Redemption, retraction, cancellation, repurchase | -39,377 vol | 17,195 | |
| Filed 2017-12-08 Tx date 2017-12-06 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -53,846 vol | 147,446 | |
| Filed 2017-12-06 Tx date 2017-12-06 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | -53,846 vol | 323,891 | |
| Filed 2017-06-28 Tx date 2017-06-28 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +18,500 vol | 201,292 | |
| Filed 2017-03-08 Tx date 2017-03-07 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +92,408 vol | 377,737 | |
| Filed 2017-01-04 Tx date 2017-01-01 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)59 - Exercise for cash | $-462,328.20 -81,828 vol $5.65 each | 56,572 | |
| Filed 2017-01-04 Tx date 2017-01-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)38 - Redemption, retraction, cancellation, repurchase | -17,193 vol | 56,572 | |
| Filed 2017-01-04 Tx date 2017-01-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)59 - Exercise for cash | $-76,269.30 -64,635 vol $1.18 each | 73,765 | |
| Filed 2016-03-24 Tx date 2016-03-23 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +102,537 vol | 285,329 | |
| Filed 2016-03-14 Tx date 2013-10-30 | $NRI Nuvo Research Inc. (formerly Dimethaid Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)56 - Grant of rights | +169,807 vol | 169,807 | |
| Filed 2016-03-14 Tx date 2013-10-30 | $NRI Nuvo Research Inc. (formerly Dimethaid Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)56 - Grant of rights | +169,447 vol | ||
| Filed 2016-03-14 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)00 - Opening Balance-Initial SEDI Report | 138,400 | ||
| Filed 2016-03-14 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)00 - Opening Balance-Initial SEDI Report | |||
| Filed 2016-03-04 Tx date 2016-03-01 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Deferred Share Unit Plan (DSU)38 - Redemption, retraction, cancellation, repurchase | -43,882 vol | 0 | |
| Filed 2016-03-04 Tx date 2016-03-01 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Deferred Share Unit Plan (DSU)36 - Conversion or exchange | -57,072 vol | 43,882 | |
| Filed 2016-03-04 Tx date 2016-03-01 | $NRI Nuvo Pharmaceuticals Inc. (formerly, Nuvo Research Inc.) | London, John 
                                4 - Director of Issuer, 5 - Senior Officer of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Common Shares36 - Conversion or exchange | +57,072 vol | 155,786 | |
| Filed 2016-03-04 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)00 - Opening Balance-Initial SEDI Report | 138,040 | ||
| Filed 2016-03-04 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options00 - Opening Balance-Initial SEDI Report | 182,792 | ||
| Filed 2016-03-04 Tx date 2016-03-01 | $CTX Crescita Therapeutics Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Common Shares00 - Opening Balance-Initial SEDI Report | 155,786 | ||
| Filed 2016-02-29 Tx date 2016-02-29 | $NRI Nuvo Research Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options97 - Other | -7 vol | 182,792 | |
| Filed 2016-01-06 Tx date 2016-01-01 | $NRI Nuvo Research Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Share Appreciation Rights Plan (SAR)59 - Exercise for cash | $-426,323.88 -81,828 vol $5.21 each | 138,040 | |
| Filed 2015-12-11 Tx date 2015-12-09 | $NRI Nuvo Research Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Warrants54 - Exercise of warrants | -10,929 vol | 0 | |
| Filed 2015-12-11 Tx date 2015-12-09 | $NRI Nuvo Research Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Common Shares54 - Exercise of warrants | $32,787 +10,929 vol $3.00 each | 98,714 | |
| Filed 2015-09-24 Tx date 2015-09-21 | $NRI Nuvo Research Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options52 - Expiration of options | $-399,997 -30,769 vol $13.00 each | 182,799 | |
| Filed 2015-06-10 Tx date 2015-06-10 | $NRI Nuvo Research Inc. | London, John 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Common Shares99 - Correction of information | -1 vol | 87,785 |