| Date | Issuer | Insider | Transaction | Amount | New Balance ⓘ 
                                    The balance of securities held by registered holder at the time of the transaction. Insiders may direct multiple registered holders and hold multiple security types.
                                 | |
|---|---|---|---|---|---|---|
| Filed 2022-01-20 18:40 Tx date 2022-01-18 | $APS Aptose Biosciences Inc. | Loewy, Caroline Marie 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +50,000 vol | 280,000 | |
| Filed 2021-01-06 20:00 Tx date 2021-01-04 | $APS Aptose Biosciences Inc. | Loewy, Caroline Marie 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +50,000 vol | 230,000 | |
| Filed 2020-03-14 13:55 Tx date 2020-03-11 | $APS Aptose Biosciences Inc. | Loewy, Caroline Marie 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +50,000 vol | 180,000 | |
| Filed 2020-02-03 11:13 Tx date 2020-01-31 | $APS Aptose Biosciences Inc. | Loewy, Caroline Marie 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +65,000 vol | 130,000 | |
| Filed 2019-01-03 Tx date 2019-01-02 | $APS Aptose Biosciences Inc. | Loewy, Caroline Marie 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +40,000 vol | 65,000 | |
| Filed 2018-04-30 Tx date 2018-04-25 | $APS Aptose Biosciences Inc. | Loewy, Caroline Marie 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options50 - Grant of options | +25,000 vol | 25,000 | |
| Filed 2018-04-30 Tx date 2018-04-25 | $APS Aptose Biosciences Inc. | Loewy, Caroline Marie 
                                4 - Director of Issuer
                             
                                
                                
                                
                                    Direct Ownership
                                
                             | Options00 - Opening Balance-Initial SEDI Report |